Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 3/20 | 0.43 |
| ▸ | CASP7 | P55210 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13522409 | 0.85 | HTT (0.64) | MAPTSMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL880405 | 0.84 | HTT (0.54) | LMNAHTTGAAGPBAR1TP53 | |
| SCHEMBL13522411 | 0.69 | HTT (0.76) | LMNAHTTKDM4EGAAHPGD | |
| SCHEMBL880259 | 0.69 | IDO1 (0.60) | LMNAGAAHSD17B10GPBAR1TP53 | |
| SCHEMBL14029127 | 0.69 | HTT (0.67) | LMNAHTTGAAHSD17B10GPBAR1 | |
| SCHEMBL9401812 | 0.68 | CACNA1B (0.65) | MAPTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL880375 | 0.68 | HTT (0.78) | LMNAHTTKDM4EALDH1A1GAA | |
| SCHEMBL17478072 | 0.67 | LMNA (0.49) | LMNAHTTGPBAR1TP53RPS6KB1 | |
| SCHEMBL156842 | 0.66 | CHRNB2 (0.56) | MAPTSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL10280605 | 0.66 | TP53 (0.64) | MAPTSMN1; SMN2LMNAHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |