Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.84 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.77 |
| ▸ | GAA | P10253 | 2/20 | 0.77 |
| ▸ | MAPT | P10636 | 11/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.74 |
| ▸ | MEN1 | O00255 | 7/20 | 0.74 |
| ▸ | HTT | P42858 | 6/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | HPGD | P15428 | 2/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13522300 | 0.92 | ALDH1A1 (0.88) | ALDH1A1KDM4ENPSR1SMN1; SMN2L3MBTL1 | |
| SCHEMBL880478 | 0.90 | ALDH1A1 (0.84) | ALDH1A1KDM4ENPSR1SMN1; SMN2L3MBTL1 | |
| SCHEMBL880481 | 0.88 | KDM4E (0.81) | ALDH1A1KDM4ENPSR1SMN1; SMN2L3MBTL1 | |
| SCHEMBL880413 | 0.83 | ALDH1A1 (0.77) | ALDH1A1KDM4ENPSR1SMN1; SMN2L3MBTL1 | |
| SCHEMBL880480 | 0.80 | MAPT (1.00) | ALDH1A1KDM4ENPSR1SMN1; SMN2L3MBTL1 | |
| SCHEMBL10280642 | 0.79 | ALDH1A1 (0.70) | ALDH1A1KDM4ENPSR1SMN1; SMN2L3MBTL1 | |
| SCHEMBL880258 | 0.79 | NPSR1 (0.92) | ALDH1A1KDM4ENPSR1SMN1; SMN2L3MBTL1 | |
| SCHEMBL29004406 | 0.78 | KDM4E (0.69) | ALDH1A1KDM4ENPSR1SMN1; SMN2L3MBTL1 | |
| SCHEMBL23160937 | 0.78 | ADCY1 (0.72) | KMT2AMEN1LMNAADCY8ADCY1 | |
| SCHEMBL23188322 | 0.78 | ADCY1 (1.00) | ADCY8ADCY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |
| US-20100004277-A1 | COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2010-01-07 | — | — | US | disclosed |
| US-20100004277-A1 | COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2010-01-07 | — | — | US | disclosed |
| WO-2007089548-A2 | COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING | FOLDRX PHARMACEUTICALS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004277-A1 | COMPOUNDS AND METHODS FOR MODULATING PROTEIN TRAFFICKING | GOLT1B, NPC1L1, NPC1 | ALDH1A1 3699/4885KDM4E 4172/4885NPSR1 2544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.