Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | SLC9A1 | P19634 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8806232 | 0.88 | TSHR (0.48) | TSHRNPSR1RXFP1SLC9A1SMN1; SMN2 | |
| SCHEMBL8804817 | 0.82 | TSHR (0.50) | TSHRNPSR1RXFP1SLC9A1SMN1; SMN2 | |
| SCHEMBL266156 | 0.82 | TSHR (0.48) | TSHRNPSR1RXFP1SLC9A1SMN1; SMN2 | |
| SCHEMBL9567914 | 0.81 | TSHR (0.47) | TSHRNPSR1RXFP1SLC9A1SMN1; SMN2 | |
| SCHEMBL14299004 | 0.80 | TSHR (0.46) | TSHRNPSR1RXFP1SLC9A1SMN1; SMN2 | |
| SCHEMBL3485080 | 0.79 | TSHR (0.50) | TSHRNPSR1RXFP1SLC9A1SMN1; SMN2 | |
| SCHEMBL11088928 | 0.79 | TSHR (0.50) | TSHRNPSR1RXFP1SLC9A1SMN1; SMN2 | |
| SCHEMBL24744740 | 0.76 | SLC9A1 (0.49) | TSHRNPSR1SLC9A1RAB9AKEAP1 | |
| SCHEMBL8804705 | 0.76 | TSHR (0.47) | TSHRNPSR1RXFP1SLC9A1SMN1; SMN2 | |
| SCHEMBL4006352 | 0.75 | TSHR (0.67) | TSHRNPSR1RXFP1SLC9A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0753525-A1 | CYCLIC NUCLEOTIDE DERIVATIVE | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1997-01-15 | — | — | EP | disclosed |