Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 7/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PDE1A | P54750 | 1/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.46 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9715610 | 0.80 | FEN1 (0.58) | FEN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10412161 | 0.80 | FEN1 (0.58) | FEN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28978594 | 0.80 | MAT2A (0.50) | ALDH1A1TSHRMEN1KMT2AKDM4E | |
| SCHEMBL29417532 | 0.80 | MAT2A (0.50) | ALDH1A1TSHRMEN1KMT2AKDM4E | |
| SCHEMBL30084688 | 0.77 | PIK3CG (0.40) | FEN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10421586 | 0.77 | FEN1 (0.56) | FEN1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29417554 | 0.77 | ALDH1A1 (0.37) | ALDH1A1TSHRMEN1KMT2AKDM4E | |
| SCHEMBL28978832 | 0.77 | MAT2A (0.42) | ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL28978823 | 0.77 | ALDH1A1 (0.37) | ALDH1A1TSHRMEN1KMT2AKDM4E | |
| SCHEMBL29417557 | 0.77 | MAT2A (0.42) | ALDH1A1MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526840-B1 | Condensed naphthyridine derivatives | KYOWA HAKKO KOGYO KK (JP) | 1997-10-22 | — | — | EP | disclosed |
| US-5281610-A | Pyrazolonaphthyridine pharmaceuticals | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-01-25 | — | — | US | disclosed |
| EP-0526840-A1 | Condensed naphthyridine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-02-10 | — | — | EP | disclosed |