SCHEMBL684179

SCHEMBL684179

Cc1nc(C)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nnn[nH]3)cn1)C(=O)C(C)C2

nearest known ligand 0.58

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 3/20 0.43
TBXA2R P21731 1/20 0.43
AGTR2 P50052 1/20 0.43
PDE3A Q14432 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8803578 0.89 AGTR1 (0.55) AGTR1TBXA2RAGTR2PDE3A
SCHEMBL8803987 0.88 AGTR1 (0.56) AGTR1TBXA2RAGTR2PDE3A
SCHEMBL7428240 0.81 AGTR1 (0.54) AGTR1TBXA2RAGTR2PDE3A
SCHEMBL8803999 0.77 AGTR1 (0.59) AGTR1TBXA2RAGTR2PDE3A
Tasosartan SCHEMBL49626 0.76 AGTR1 (0.71) AGTR1TBXA2RAGTR2PDE3A
SCHEMBL683802 0.73 AGTR1 (0.50) AGTR1TBXA2RAGTR2PDE3A
SCHEMBL7426784 0.72 AGTR1 (0.49) AGTR1TBXA2RAGTR2PDE3A
SCHEMBL683800 0.72 AGTR1 (0.55) AGTR1TBXA2RAGTR2PDE3A
Water SCHEMBL7438445 0.72 AGTR1 (0.49) AGTR1TBXA2RAGTR2PDE3A
SCHEMBL7429405 0.71 AGTR1 (0.61) AGTR1TBXA2RAGTR2PDE3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN BRAINCELLS INC. (US) 2011-11-03 US disclosed
US-20110046090-A1 MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS BRAINCELLS INC. (US) 2011-02-24 US disclosed
US-20110046090-A1 MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS BRAINCELLS INC. (US) 2011-02-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110046090-A1 MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS GAP43, GABRB1, GABRB3 AGTR1 3252/4885TBXA2R 442/4885AGTR2 2610/4885
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN NGF, DCX, BDNF AGTR1 8/4885TBXA2R 1092/4885AGTR2 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.