Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RBP4 | P02753 | 2/20 | 0.40 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | F2R | P25116 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | ICMT | O60725 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8803968 | 0.91 | ACAT1 (0.42) | GAAKMT2AACAT1F2RPPARG | |
| SCHEMBL8803723 | 0.87 | SOAT1 (0.47) | ACAT1HDAC3HDAC1HDAC2PPARG | |
| SCHEMBL8805548 | 0.84 | UBE2M (0.39) | GAAKMT2APPARGPPARAICMT | |
| SCHEMBL8807292 | 0.82 | POLB (0.55) | GAAKMT2AALDH1A1HTTMEN1 | |
| SCHEMBL8806543 | 0.82 | POLB (0.55) | GAAKMT2AALDH1A1HTTMEN1 | |
| SCHEMBL8803021 | 0.80 | ABCC1 (0.43) | GAARBP4ALDH1A1LMNAAGTR1 | |
| SCHEMBL8804984 | 0.80 | GAA (0.38) | GAAKMT2AACAT1ALDH1A1LMNA | |
| SCHEMBL8805315 | 0.79 | POLB (0.60) | GAAKMT2AALDH1A1LMNAHTT | |
| SCHEMBL8803801 | 0.79 | RBP4 (0.39) | RBP4ACAT1F2RALDH1A1HDAC3 | |
| SCHEMBL8803793 | 0.79 | RBP4 (0.39) | RBP4ACAT1F2RALDH1A1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625507-B1 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO (JP) | 1997-07-23 | — | — | EP | disclosed |
| US-5621010-A | ANTIHYPERCHOLESTEROLEMIA AND ANTIATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0625507-A2 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1994-11-23 | — | — | EP | disclosed |