Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10280290 | 0.84 | LMNA (0.70) | SMN1; SMN2ALDH1A1POLBLMNAGAA | |
| SCHEMBL880218 | 0.82 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1POLBLMNAGAA | |
| SCHEMBL880460 | 0.81 | KMT2A (0.64) | SMN1; SMN2ALDH1A1POLBLMNAGAA | |
| SCHEMBL880366 | 0.80 | TP53 (0.67) | SMN1; SMN2ALDH1A1POLBLMNAGAA | |
| SCHEMBL880216 | 0.79 | TP53 (0.60) | SMN1; SMN2ALDH1A1POLBLMNAGAA | |
| SCHEMBL880352 | 0.76 | KMT2A (0.73) | SMN1; SMN2ALDH1A1POLBLMNAGAA | |
| SCHEMBL14264660 | 0.76 | CYP19A1 (0.59) | ALDH1A1LMNAMAPT | |
| SCHEMBL880458 | 0.75 | KMT2A (0.68) | SMN1; SMN2ALDH1A1POLBLMNAGAA | |
| SCHEMBL14942698 | 0.74 | LMNA (0.55) | SMN1; SMN2ALDH1A1POLBLMNAKMT2A | |
| SCHEMBL17478253 | 0.72 | RPS6KB1 (0.55) | POLBLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440705-B2 | 2,3,4,7,8,9-hexahydro-1H-cyclopenta[h]quinolin-2-one or 2,3,4,6,7,8-hexahydro-1H-cyclopenta[g]quinolin-2-one; Alzheimer's disease | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2013-05-14 | — | — | US | disclosed |
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |