Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.53 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8803423 | 0.90 | MAOA (0.48) | MAOAMAOBSCN9A | |
| SCHEMBL8803242 | 0.85 | MAOB (0.64) | MAOAMAOBSCN9AMEN1KMT2A | |
| SCHEMBL9201087 | 0.84 | MAOA (0.62) | MAOAMAOBSCN9A | |
| SCHEMBL8804579 | 0.84 | MAOA (0.62) | MAOAMAOBSCN9A | |
| Hydrochloric Acid SCHEMBL5967428 | 0.83 | MAOA (0.61) | MAOAMAOBSCN9A | |
| SCHEMBL17666275 | 0.80 | MAOA (0.65) | MAOAMAOBSCN9A | |
| SCHEMBL23440934 | 0.79 | MAOB (0.65) | MAOAMAOBSCN9A | |
| SCHEMBL8802147 | 0.78 | ALDH1A1 (0.60) | MAOAMAOBSCN9AMEN1KMT2A | |
| SCHEMBL21346322 | 0.77 | TSHR (0.53) | TACR1MEN1KMT2A | |
| SCHEMBL23440921 | 0.77 | MAOB (0.67) | MAOAMAOBSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775140-A1 | SPIRO-SUBSTITUTED AZACYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005203-A1 | SPIRO-SUBSTITUTED AZACYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |