Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.51 |
| ▸ | ELANE | P08246 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 2/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8901056 | 0.83 | PTPN1 (0.50) | LMNATSHRHSD17B10POLBPTPN1 | |
| SCHEMBL7848040 | 0.81 | PTGDR2 (0.54) | LMNATSHRPTGDR2POLBSMN1; SMN2 | |
| SCHEMBL25685569 | 0.81 | POLB (0.64) | LMNAPTGDR2ELANEHSD17B10POLB | |
| SCHEMBL4134156 | 0.80 | LMNA (0.58) | LMNAPTGDR2HSD17B10POLBSMN1; SMN2 | |
| SCHEMBL590943 | 0.78 | APLNR (0.63) | TSHR | |
| SCHEMBL2225179 | 0.78 | LMNA (0.57) | LMNATSHRPTGDR2POLBSMN1; SMN2 | |
| SCHEMBL5394389 | 0.78 | TSHR (0.71) | LMNATSHRHSD17B10POLBSMN1; SMN2 | |
| SCHEMBL8702709 | 0.77 | LMNA (0.55) | LMNATSHRPTGDR2ELANEHSD17B10 | |
| SCHEMBL4975454 | 0.76 | PKM (0.64) | LMNATSHRPTGDR2ELANEHSD17B10 | |
| SCHEMBL28566630 | 0.76 | PPARD (0.67) | LMNAPTGDR2ELANEPPARDMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700807-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-23 | — | — | US | disclosed |
| EP-0755934-A1 | Endothelin receptor antagonists | MERCK PATENT GmbH (DE) | 1997-01-29 | — | — | EP | disclosed |