Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 7/20 | 0.42 |
| ▸ | WNT3A | P56704 | 7/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9461947 | 0.80 | FNIP1 (0.48) | — | |
| SCHEMBL14403556 | 0.73 | CTNNB1 (0.46) | CTNNB1WNT3ACLK1DYRK1ADYRK1B | |
| SCHEMBL577552 | 0.71 | CLK1 (0.46) | CTNNB1WNT3ACLK1DYRK1ADYRK1B | |
| SCHEMBL29397421 | 0.71 | CLK1 (0.46) | CTNNB1WNT3ACLK1DYRK1ADYRK1B | |
| SCHEMBL10549128 | 0.71 | CLK1 (0.46) | CTNNB1WNT3ACLK1DYRK1ADYRK1B | |
| SCHEMBL17030554 | 0.70 | CTNNB1 (0.42) | CTNNB1WNT3ACLK1DYRK1ADYRK1B | |
| SCHEMBL27342125 | 0.70 | CTNNB1 (0.46) | CTNNB1WNT3ACLK1DYRK1ADYRK1B | |
| Oxirane SCHEMBL27706875 | 0.68 | ALK (0.44) | CTNNB1WNT3ACLK1DYRK1ADYRK1B | |
| SCHEMBL13193134 | 0.68 | CTNNB1 (0.68) | CTNNB1WNT3APRKCI | |
| SCHEMBL23653205 | 0.67 | DYRK1A (0.46) | CTNNB1WNT3ACLK1DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0648767-B1 | Piperdine and piperazine derivatives which affect the C.N.S. | MERCK PATENT GMBH (DE) | 1997-05-28 | — | — | EP | disclosed |
| US-5532241-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-02 | — | — | US | disclosed |
| EP-0648767-A1 | Piperdine and piperazine derivatives which affect the C.N.S. | MERCK PATENT GmbH (DE) | 1995-04-19 | — | — | EP | disclosed |