Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447285 | 0.92 | RAB9A (0.42) | RAB9AMAPK1OPRK1NPSR1SMN1; SMN2 | |
| SCHEMBL7449927 | 0.85 | SMN1; SMN2 (0.43) | RAB9ANPSR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7442181 | 0.85 | ALDH1A1 (0.42) | RAB9AMAPK1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8804534 | 0.83 | KDM4E (0.41) | RAB9AOPRK1NPSR1SMN1; SMN2KDM4E | |
| SCHEMBL7441237 | 0.83 | ALDH1A1 (0.47) | RAB9ANPSR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7493819 | 0.83 | ALDH1A1 (0.44) | RAB9AMAPK1OPRK1SMN1; SMN2KDM4E | |
| SCHEMBL7442622 | 0.82 | SMN1; SMN2 (0.40) | RAB9ASMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL7435479 | 0.82 | SMPD1 (0.46) | RAB9ASMN1; SMN2KDM4EALDH1A1NPC1 | |
| SCHEMBL7444167 | 0.80 | ALDH1A1 (0.42) | RAB9ANPSR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7436869 | 0.80 | ALDH1A1 (0.40) | RAB9ASMN1; SMN2KDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546102-B1 | TROPOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR PREVENTING AND TREATING ISCHEMIC DISEASES | UPJOHN CO (US) | 1997-10-15 | — | — | EP | claimed |
| US-5703071-A | Tropolone derivatives and pharmaceutical composition thereof for preventing and treating ischemic diseases | PHARMACIA & UPJOHN COMPANY (US) | 1997-12-30 | — | — | US | disclosed |
| EP-0546102-B1 | TROPOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR PREVENTING AND TREATING ISCHEMIC DISEASES | UPJOHN CO (US) | 1997-10-15 | — | — | EP | disclosed |
| US-5594144-A | TREATING CEREBROVASCULAR AND CARDIOVASCULAR DISORDERS | THE UPJOHN COMPANY (US) | 1997-01-14 | — | — | US | disclosed |