Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 10/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8804534 | 0.89 | KDM4E (0.41) | SMPD1SIGMAR1KDM4ENPC1ALDH1A1 | |
| SCHEMBL7447285 | 0.89 | RAB9A (0.42) | KDM4ENPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL8913555 | 0.86 | ALDH1A1 (0.38) | SIGMAR1KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL7442181 | 0.85 | ALDH1A1 (0.42) | ABCB1KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL7449927 | 0.84 | SMN1; SMN2 (0.43) | KDM4ENPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL8805992 | 0.82 | RAB9A (0.45) | SMPD1KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL7493819 | 0.81 | ALDH1A1 (0.44) | SIGMAR1KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL7441237 | 0.78 | ALDH1A1 (0.47) | KDM4ENPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL7442622 | 0.77 | SMN1; SMN2 (0.40) | KDM4ENPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL8915492 | 0.77 | HTR6 (0.35) | SIGMAR1ABCB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546102-B1 | TROPOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR PREVENTING AND TREATING ISCHEMIC DISEASES | UPJOHN CO (US) | 1997-10-15 | — | — | EP | claimed |
| WO-1992004338-A1 | TROPOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR PREVENTING AND TREATING ISCHEMIC DISEASES | THE UPJOHN COMPANY (US) | 1992-03-19 | — | — | WO | claimed |
| EP-0546102-B1 | TROPOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR PREVENTING AND TREATING ISCHEMIC DISEASES | UPJOHN CO (US) | 1997-10-15 | — | — | EP | disclosed |
| US-5594144-A | TREATING CEREBROVASCULAR AND CARDIOVASCULAR DISORDERS | THE UPJOHN COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| WO-1992004338-A1 | TROPOLONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION THEREOF FOR PREVENTING AND TREATING ISCHEMIC DISEASES | THE UPJOHN COMPANY (US) | 1992-03-19 | — | — | WO | disclosed |