Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HTR1F | P30939 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8805580 | 0.87 | KDM4E (0.59) | DRD2HTR2ALMNASMN1; SMN2KDM4E | |
| SCHEMBL8805772 | 0.83 | DRD2 (0.61) | DRD2EPHX2HTR2AKDM4ECYP1A2 | |
| SCHEMBL1583103 | 0.83 | KDM4E (0.69) | DRD2HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL13904318 | 0.82 | HRH3 (0.73) | DRD2HTR2AKDM4ECYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL7407551 | 0.81 | KDM4E (0.67) | DRD2HTR2AKDM4ECYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL7407548 | 0.81 | KDM4E (0.67) | DRD2HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL8807468 | 0.81 | DRD2 (0.58) | DRD2HTR2AKDM4ECYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL7414903 | 0.81 | HRH3 (0.71) | DRD2HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL8806802 | 0.81 | DRD2 (0.65) | DRD2HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL8808595 | 0.81 | HSD11B1 (0.58) | DRD2EPHX2HTR2AKDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0751936-A1 | NEW 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS MEDICAMENTS ACTING ON THE GLUTAMATE RECEPTOR | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-01-08 | — | — | EP | disclosed |
| WO-1995025721-A1 | NEW 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS MEDICAMENTS ACTING ON THE GLUTAMATE RECEPTOR | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-09-28 | — | — | WO | disclosed |