Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8805772 | 0.97 | DRD2 (0.61) | HSD11B1DRD2HTR2AKDM4ECYP1A2 | |
| SCHEMBL8805802 | 0.94 | HSD11B1 (0.60) | HSD11B1DRD2HTR2AKDM4ECYP1A2 | |
| SCHEMBL8807468 | 0.89 | DRD2 (0.58) | DRD2HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL8807551 | 0.86 | DRD2 (0.57) | DRD2HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL8805341 | 0.85 | DRD2 (0.62) | DRD2 | |
| SCHEMBL8812016 | 0.83 | ADRB2 (0.57) | HSD11B1CYP2D6 | |
| SCHEMBL8813180 | 0.81 | HSD11B1 (0.55) | HSD11B1DRD2HTR2ACYP2D6HTR2C | |
| SCHEMBL1583103 | 0.81 | KDM4E (0.69) | DRD2HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL8806604 | 0.81 | DRD2 (0.60) | DRD2HTR2AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL8805880 | 0.80 | HSD11B1 (0.53) | HSD11B1DRD2HTR2ACYP2D6HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0751936-A1 | NEW 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS MEDICAMENTS ACTING ON THE GLUTAMATE RECEPTOR | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-01-08 | — | — | EP | disclosed |
| WO-1995025721-A1 | NEW 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS MEDICAMENTS ACTING ON THE GLUTAMATE RECEPTOR | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-09-28 | — | — | WO | disclosed |