Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.38 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 14/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557846 | 0.89 | TACR1 (0.43) | TACR1 | |
| SCHEMBL8806614 | 0.89 | TACR1 (0.42) | TACR1 | |
| SCHEMBL8562444 | 0.89 | TACR1 (0.41) | TAOK1TAOK3TACR1LMNAMAPT | |
| SCHEMBL8812887 | 0.88 | TACR1 (0.42) | TACR1 | |
| SCHEMBL8563071 | 0.85 | TACR1 (0.52) | TACR1 | |
| SCHEMBL8561970 | 0.84 | TACR1 (0.38) | TACR1 | |
| Hydrochloric Acid SCHEMBL8565628 | 0.84 | TACR1 (0.51) | TACR1 | |
| SCHEMBL8562658 | 0.84 | TACR1 (0.47) | TACR1 | |
| SCHEMBL8807964 | 0.84 | TACR1 (0.41) | TACR1 | |
| SCHEMBL8563364 | 0.83 | TACR1 (0.47) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775140-A1 | SPIRO-SUBSTITUTED AZACYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005203-A1 | SPIRO-SUBSTITUTED AZACYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |