Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 14/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10681531 | 0.87 | CHRNA7 (0.52) | TBXAS1CYP1A2CYP2D6HRH4HRH3 | |
| SCHEMBL11066566 | 0.84 | TBXAS1 (0.52) | TBXAS1ALDH1A1 | |
| SCHEMBL17541046 | 0.83 | TBXAS1 (0.48) | TBXAS1CYP1A2CYP2D6KDM4EALDH1A1 | |
| SCHEMBL727185 | 0.82 | CYP1A2 (0.62) | TBXAS1CYP1A2CYP2D6CYP11B1CYP11B2 | |
| Formic Acid SCHEMBL27652252 | 0.81 | TBXAS1 (0.61) | TBXAS1CYP1A2CYP2D6CYP11B1CYP11B2 | |
| SCHEMBL10659378 | 0.81 | TBXAS1 (0.67) | TBXAS1ALDH1A1 | |
| SCHEMBL10659382 | 0.81 | TBXAS1 (0.67) | TBXAS1ALDH1A1 | |
| SCHEMBL9401843 | 0.81 | TBXAS1 (0.64) | TBXAS1CYP1A2CYP2D6CYP11B1CYP11B2 | |
| SCHEMBL9401838 | 0.81 | TBXAS1 (0.64) | TBXAS1CYP1A2CYP2D6CYP11B1CYP11B2 | |
| Formic Acid SCHEMBL27873643 | 0.80 | TBXAS1 (0.59) | TBXAS1CYP1A2CYP2D6CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |
| US-4427682-A | ANTICOAGULANTS, ANTIINFLAMMATORY, HYPOTENSIVE, OR ANTIALLERGEN AGENTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1984-01-24 | — | — | US | disclosed |
| US-4317828-A | ANTIINFLAMMATORY AGENTS, HYPOTENSIVE AGENTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1982-03-02 | — | — | US | disclosed |
| US-4271170-A | THROMBOXANE SYNTHETASE ENZYME INHIBITOR USEFUL IN TREATING INFLAMMATION, HYPERTENSION, THROMBUS, CEREBRAL APOPLEXY, ASTHMA, AND CARDIOVASCULAR DISORDERS | ONO PHARMACEUTICAL CO., LTD., (JP) | 1981-06-02 | — | — | US | disclosed |