Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SLC34A2 | O95436 | 3/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807326 | 0.89 | BCHE (0.47) | MAPTMEN1KMT2AROCK2CYP3A4 | |
| SCHEMBL8806850 | 0.78 | MEN1 (0.53) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8808218 | 0.75 | ABCG2 (0.44) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8806416 | 0.74 | TP53 (0.53) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8807862 | 0.73 | ABCG2 (0.43) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8808186 | 0.73 | CYP3A4 (0.64) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8807455 | 0.72 | MEN1 (0.53) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8808932 | 0.72 | MEN1 (0.52) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8809638 | 0.71 | F10 (0.42) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8809319 | 0.71 | MEN1 (0.61) | MAPTNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |