Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | ACHE | P22303 | 3/20 | 0.48 |
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8806840 | 0.86 | ACHE (0.56) | MEN1KMT2AROCK2CYP3A4ACHE | |
| SCHEMBL8807455 | 0.86 | MEN1 (0.53) | MEN1KMT2ACYP3A4MAPTCYP1A2 | |
| SCHEMBL8807334 | 0.78 | MAPT (0.42) | MEN1KMT2AROCK2CYP3A4ACHE | |
| SCHEMBL8806857 | 0.77 | MEN1 (0.48) | MEN1KMT2AROCK2CYP3A4ACHE | |
| SCHEMBL8807451 | 0.77 | ACHE (0.55) | MEN1KMT2AROCK2CYP3A4ACHE | |
| SCHEMBL8809264 | 0.75 | ABCG2 (0.41) | MEN1KMT2AROCK2CYP3A4MAPT | |
| SCHEMBL8807954 | 0.75 | F10 (0.43) | MEN1KMT2AROCK2CYP3A4MAPT | |
| SCHEMBL8808932 | 0.74 | MEN1 (0.52) | MEN1KMT2AMAPTPOLBRAB9A | |
| SCHEMBL8807055 | 0.74 | ABCG2 (0.43) | MEN1KMT2AROCK2CYP3A4MAPT | |
| SCHEMBL8830721 | 0.74 | CYP3A4 (0.65) | MEN1KMT2ACYP3A4MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |