Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808344 | 0.92 | ACHE (0.49) | MAOBADORA2BTP53MAPTKDM4E | |
| SCHEMBL8808718 | 0.89 | MAPT (0.48) | MAOBADORA2BMEN1KMT2AABCB1 | |
| SCHEMBL8789962 | 0.83 | ABCG2 (0.65) | MEN1KMT2AABCB1TP53ABCG2 | |
| SCHEMBL8790105 | 0.83 | ABCG2 (0.61) | MEN1KMT2AABCB1TP53ABCG2 | |
| SCHEMBL8830578 | 0.83 | MAOB (0.45) | MAOBADORA2BMEN1KMT2AABCB1 | |
| SCHEMBL8815521 | 0.82 | ACHE (0.52) | MAPTKDM4EALDH1A1LMNANPSR1 | |
| SCHEMBL8831005 | 0.82 | MAPT (0.49) | MAOBADORA2BMEN1KMT2AABCB1 | |
| SCHEMBL8789246 | 0.81 | ABCG2 (0.66) | MEN1KMT2AABCB1TP53ABCG2 | |
| SCHEMBL8807015 | 0.80 | ABCG2 (0.44) | MEN1KMT2AABCB1TP53ABCG2 | |
| SCHEMBL8789562 | 0.80 | ABCG2 (0.69) | MEN1KMT2AABCB1TP53ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |