Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18511929 | 0.77 | HPGD (0.67) | NPC1RAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL27791058 | 0.74 | KMT2A (0.46) | NPC1RAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL17552096 | 0.73 | NPC1 (0.69) | NPC1RAB9AALDH1A1HTTNCEH1 | |
| SCHEMBL5108159 | 0.73 | NPC1 (0.69) | NPC1RAB9AALDH1A1HTTNCEH1 | |
| SCHEMBL1720194 | 0.72 | ALDH1A1 (0.67) | NPC1ALDH1A1SMN1; SMN2BCHEHPGD | |
| SCHEMBL1249499 | 0.72 | KDM4E (0.39) | ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9655074 | 0.72 | NPC1 (0.52) | NPC1RAB9AALDH1A1SMN1; SMN2NCEH1 | |
| SCHEMBL14080775 | 0.72 | RAB9A (0.68) | NPC1RAB9AALDH1A1HTT | |
| SCHEMBL28058232 | 0.71 | BCHE (0.55) | ALDH1A1SMN1; SMN2BCHENCEH1HPGD | |
| SCHEMBL30776776 | 0.71 | NPC1 (0.67) | NPC1RAB9AALDH1A1HTTNCEH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0320628-B1 | Substituted furan compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase | ABBOTT LAB (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5112848-A | Antiasthmatics and antiarthritic agents | ABBOTT LABORATORIES (US) | 1992-05-12 | — | — | US | disclosed |
| EP-0388429-A4 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | — | 1991-08-21 | — | — | EP | disclosed |
| EP-0388429-A1 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1990-09-26 | — | — | EP | disclosed |
| EP-0320628-A1 | Substituted furan compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase | ABBOTT LABORATORIES (US) | 1989-06-21 | — | — | EP | disclosed |
| WO-1989004299-A1 | FURAN AND PYRROLE CONTAINING LIPOXYGENASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-05-18 | — | — | WO | disclosed |