Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807272 | 0.79 | EGFR (0.48) | EGFRPDE3BPDE3APDE5AHPGD | |
| SCHEMBL1806077 | 0.79 | ENPP1 (0.49) | EGFRKMT2APDE5AENPP1AURKA | |
| SCHEMBL3275840 | 0.77 | SRC (0.63) | EGFRPDE3BPDE3ASRC | |
| SCHEMBL30782464 | 0.77 | KMT2A (0.54) | EGFRKMT2AENPP1AURKAHPGD | |
| SCHEMBL1478679 | 0.77 | KMT2A (0.54) | EGFRKMT2AENPP1AURKAHPGD | |
| SCHEMBL2948476 | 0.76 | PDE3B (0.53) | PDE3BPDE3AKMT2AHPGDMEN1 | |
| SCHEMBL26006397 | 0.75 | MERTK (0.38) | EGFRKMT2AMEN1DYRK1ADYRK1B | |
| SCHEMBL1807216 | 0.75 | ENPP1 (0.48) | EGFRKMT2APDE5AENPP1AURKA | |
| SCHEMBL28038544 | 0.75 | PDE3B (0.51) | PDE3BPDE3AHPGDAMY1AALDH1A1 | |
| SCHEMBL8518250 | 0.73 | ALDH1A1 (0.44) | EGFRPDE3BPDE3APDE5AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782570-A1 | SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009294-A1 | SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |