Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.53 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28038544 | 0.85 | PDE3B (0.51) | PDE3BPDE3AAMY1AALDH1A1KDM4E | |
| SCHEMBL27248807 | 0.84 | PDE3B (0.40) | PDE3BPDE3AAMY1AALDH1A1KDM4E | |
| SCHEMBL27248563 | 0.84 | ALDH1A1 (0.37) | PDE3BPDE3AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4738100 | 0.83 | PDE3A (0.50) | PDE3BPDE3AAMY1AALDH1A1HPGD | |
| SCHEMBL27248956 | 0.83 | PDE3B (0.42) | PDE3BPDE3AALDH1A1KDM4EHPGD | |
| SCHEMBL11209986 | 0.79 | SMN1; SMN2 (0.45) | PDE3BPDE3AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL30402363 | 0.77 | ALDH1A1 (0.53) | AMY1AALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL1478324 | 0.77 | ALDH1A1 (0.53) | AMY1AALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL8807809 | 0.76 | EGFR (0.48) | PDE3BPDE3AAMY1AALDH1A1KDM4E | |
| SCHEMBL16689300 | 0.75 | SMN1; SMN2 (0.44) | AMY1AALDH1A1KDM4ESMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227450-A2 | Substituted 5,6-Dialkoxyquinazoline Derivatives | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-07-01 | — | — | EP | claimed |
| US-4672116-A | CARDIOTONIC AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-06-09 | — | — | US | claimed |
| US-20240408092-A1 | PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND THEIR USES | UNIV CASE WESTERN RESERVE (US) | 2024-12-12 | — | — | US | disclosed |
| US-11944624-B2 | Peptide and small molecule agonists of EphA and their uses | CASE WESTERN RESERVE UNIVERSITY (US) | 2024-04-02 | — | — | US | disclosed |
| US-20200222405-A1 | PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND THEIR USES | CASE WESTERN RESERVE UNIVERSITY | 2020-07-16 | — | — | US | disclosed |
| EP-3648766-A1 | PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND THEIR USES | Case Western Reserve University (US) | 2020-05-13 | — | — | EP | disclosed |
| WO-2019010180-A1 | PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND THEIR USES | CASE WESTERN RESERVE UNIVERSITY (US) | 2019-01-10 | — | — | WO | disclosed |
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | AMBIT BIOSCIENCES CORPORATION | 2010-07-08 | — | — | US | disclosed |
| US-7750160-B2 | Isoxazolyl urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-07-06 | — | — | US | disclosed |
| EP-1684762-A4 | UREA DERIVATIVES AS KINASE MODULATORS | AMBIT BIOSCIENCES CORP (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-1684762-A2 | UREA DERIVATIVES AS KINASE MODULATORS | Ambit Biosciences Corporation (US) | 2006-08-02 | — | — | EP | disclosed |
| US-20050267182-A1 | Urea derivatives as FLT-3 modulators | AMBIT BIOSCIENCES CORPORATION | 2005-12-01 | — | — | US | disclosed |
| US-20050197371-A1 | Urea derivatives as PDGFR modulators | AMBIT BIOSCIENCES CORPORATION | 2005-09-08 | — | — | US | disclosed |
| US-20050192314-A1 | Urea derivatives as C-kit modulators | AMBIT BIOSCIENCES CORPORATION | 2005-09-01 | — | — | US | disclosed |
| US-20050165031-A1 | Urea derivatives as ABL modulators | AMBIT BIOSCIENCES CORPORATION | 2005-07-28 | — | — | US | disclosed |
| US-20050165024-A1 | Urea derivatives as kinase modulators | AMBIT BIOSCIENCES CORPORATION | 2005-07-28 | — | — | US | disclosed |
| WO-2005048948-A2 | UREA DERIVATIVES AS KINASE MODULATORS | AMBIT BIOSCIENCES CORPORATION (US) | 2005-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200222405-A1 | PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND THEIR USES | EPHA1, EPHA7, EPHA3 | PDE3B 1497/4885PDE3A 1665/4885AMY1A 3793/4885 |
| US-20050165024-A1 | Urea derivatives as kinase modulators | ULK2, ULK1, ULK3 | PDE3B 775/4885PDE3A 788/4885AMY1A 3856/4885 |
| US-20100173917-A1 | UREA DERIVATIVES AS ABL MODULATORS | ABL1, ABL2, BCR | PDE3B 1141/4885PDE3A 956/4885AMY1A 4856/4885 |
| US-20050192314-A1 | Urea derivatives as C-kit modulators | KIT, PRKCH, PRKCE | PDE3B 336/4885PDE3A 385/4885AMY1A 4150/4885 |
| US-20050267182-A1 | Urea derivatives as FLT-3 modulators | FLT4, FLT1, FLT3 | PDE3B 51/4885PDE3A 41/4885AMY1A 4834/4885 |
| US-11944624-B2 | Peptide and small molecule agonists of EphA and their uses | EPHA1, EPHA7, EPHA3 | PDE3B 1497/4885PDE3A 1665/4885AMY1A 3793/4885 |
| US-20240408092-A1 | PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND THEIR USES | EPHA1, EPHA7, EPHA3 | PDE3B 1497/4885PDE3A 1665/4885AMY1A 3793/4885 |
| US-20050197371-A1 | Urea derivatives as PDGFR modulators | PDGFRA, PDGFRB, PDGFA | PDE3B 132/4885PDE3A 148/4885AMY1A 4772/4885 |
| US-20050165031-A1 | Urea derivatives as ABL modulators | ABL1, ABL2, BCR | PDE3B 1141/4885PDE3A 956/4885AMY1A 4856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.