Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 17/20 | 0.88 |
| ▸ | ABCB1 | P08183 | 15/20 | 0.88 |
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
| ▸ | DRD1 | P21728 | 1/20 | 0.65 |
| ▸ | DRD4 | P21917 | 1/20 | 0.65 |
| ▸ | DRD3 | P35462 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8812802 | 0.94 | ABCG2 (1.00) | ABCG2ABCB1 | |
| SCHEMBL8809186 | 0.89 | ABCG2 (0.78) | ABCG2ABCB1DRD2DRD1DRD4 | |
| SCHEMBL8806791 | 0.87 | ABCB1 (0.76) | ABCG2ABCB1 | |
| SCHEMBL8806779 | 0.87 | ABCG2 (0.67) | ABCG2ABCB1 | |
| SCHEMBL8807897 | 0.86 | ABCB1 (0.68) | ABCG2ABCB1DRD4DRD3 | |
| SCHEMBL8809428 | 0.86 | ABCB1 (0.89) | ABCG2ABCB1 | |
| SCHEMBL8807751 | 0.85 | ABCG2 (0.91) | ABCG2ABCB1 | |
| SCHEMBL8809137 | 0.85 | ABCG2 (0.70) | ABCG2ABCB1 | |
| SCHEMBL8807182 | 0.84 | ABCB1 (0.66) | ABCG2ABCB1 | |
| SCHEMBL14722808 | 0.84 | DRD3 (0.90) | ABCG2ABCB1DRD2DRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |