Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 13/20 | 0.90 |
| ▸ | DRD4 | P21917 | 11/20 | 0.90 |
| ▸ | DRD2 | P14416 | 8/20 | 0.90 |
| ▸ | DRD1 | P21728 | 7/20 | 0.90 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.67 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 4/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.66 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.66 |
| ▸ | HTR2A | P28223 | 2/20 | 0.66 |
| ▸ | HTR2C | P28335 | 2/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.66 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.66 |
| ▸ | HTR2B | P41595 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14721849 | 0.89 | DRD3 (0.79) | DRD3DRD4DRD2DRD1TMEM97 | |
| SCHEMBL14720483 | 0.87 | HRH4 (0.74) | DRD3DRD4DRD2DRD1ADRA1A | |
| SCHEMBL8808167 | 0.84 | ABCG2 (0.88) | DRD3DRD4DRD2DRD1ABCB1 | |
| SCHEMBL8809186 | 0.83 | ABCG2 (0.78) | DRD3DRD4DRD2DRD1ABCB1 | |
| SCHEMBL12123762 | 0.82 | ALDH1A1 (0.74) | DRD3DRD4DRD2DRD1ABCB1 | |
| SCHEMBL8812802 | 0.80 | ABCG2 (1.00) | ABCB1ABCG2 | |
| Bp-897 SCHEMBL2125882 | 0.80 | DRD2 (1.00) | DRD3DRD4DRD2DRD1HTR1A | |
| Bp-897 SCHEMBL30027453 | 0.80 | DRD2 (1.00) | DRD3DRD4DRD2DRD1HTR1A | |
| Bp-897 SCHEMBL29382551 | 0.80 | DRD2 (1.00) | DRD3DRD4DRD2DRD1HTR1A | |
| SCHEMBL8285661 | 0.79 | SIGMAR1 (1.00) | DRD3DRD4DRD2TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170349554-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | COGNITION THERAPEUTICS, INC. | 2017-12-07 | — | — | US | disclosed |
| CN-107260726-A | Composition and method for treating nerve degenerative diseases | 考格尼申治疗股份有限公司 | 2017-10-20 | — | — | CN | disclosed |
| US-20140378460-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | COGNITION THERAPEUTICS, INC. (US) | 2014-12-25 | — | — | US | disclosed |
| CN-104053436-A | Compositions and methods for treating neurodegenerative diseases | COGNITION THERAPEUTICS INC | 2014-09-17 | — | — | CN | disclosed |
| EP-2747768-A2 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | Cognition Therapeutics, Inc. (US) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013029060-A2 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | COGNITION THERAPEUTICS, INC. (US) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378460-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | TMEM97, SLC18A2, SIGMAR1 | DRD3 475/4885DRD4 533/4885DRD2 164/4885 |
| US-20170349554-A1 | COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE | TMEM97, SLC18A2, SIGMAR1 | DRD3 475/4885DRD4 533/4885DRD2 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.