Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8807856 | 0.98 | ABCG2 (0.45) | ABCG2ABCB1ACHEBCHEMCHR1 | |
| SCHEMBL8808218 | 0.91 | ABCG2 (0.44) | ABCG2ABCB1TP53MAPTKDM4E | |
| SCHEMBL8808995 | 0.90 | MCHR1 (0.49) | ABCG2ABCB1ACHEBCHEMCHR1 | |
| SCHEMBL8807862 | 0.89 | ABCG2 (0.43) | ABCG2ABCB1TP53MAPTRAF1 | |
| SCHEMBL8788454 | 0.85 | ABCG2 (0.64) | ABCG2ABCB1ACHEBCHEOPRM1 | |
| SCHEMBL8790168 | 0.85 | ABCG2 (0.62) | ABCG2ABCB1ACHEBCHEOPRM1 | |
| SCHEMBL8790232 | 0.83 | ABCG2 (0.54) | ABCG2ABCB1ACHEBCHEOPRM1 | |
| SCHEMBL8789989 | 0.83 | ABCG2 (0.63) | ABCG2ABCB1ACHEBCHEOPRM1 | |
| SCHEMBL8815851 | 0.83 | BCHE (0.43) | ABCG2ABCB1ACHEBCHEMCHR1 | |
| SCHEMBL8808228 | 0.83 | ABCG2 (0.43) | ABCG2ABCB1MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |