Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 3/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808214 | 0.90 | ABCG2 (0.46) | MCHR1BCHEACHEABCG2ALOX5 | |
| SCHEMBL8807856 | 0.90 | ABCG2 (0.45) | MCHR1BCHEACHEABCG2ALOX5 | |
| SCHEMBL8809001 | 0.88 | KDR (0.47) | MCHR1KDRABCG2MEN1KMT2A | |
| SCHEMBL8788702 | 0.86 | ABCG2 (0.59) | MCHR1KDRBCHEACHEABCG2 | |
| SCHEMBL8789576 | 0.86 | ABCG2 (0.56) | MCHR1KDRBCHEACHEABCG2 | |
| SCHEMBL8789201 | 0.83 | ABCG2 (0.59) | KDRBCHEACHEABCG2MEN1 | |
| SCHEMBL8790765 | 0.82 | ABCG2 (0.56) | KDRBCHEACHEABCG2OPRM1 | |
| SCHEMBL8808218 | 0.81 | ABCG2 (0.44) | ABCG2MEN1KMT2AABCB1TP53 | |
| SCHEMBL8789467 | 0.81 | ABCG2 (0.49) | KDRBCHEACHEABCG2OPRM1 | |
| SCHEMBL8815851 | 0.81 | BCHE (0.43) | MCHR1KDRBCHEACHEABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |