Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | VHL | P40337 | 1/20 | 0.46 |
| ▸ | ELOC | Q15369 | 1/20 | 0.46 |
| ▸ | ELOB | Q15370 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 8/20 | 0.35 |
| ▸ | RARA | P10276 | 6/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.35 |
| ▸ | RXRG | P48443 | 3/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | RARB | P10826 | 6/20 | 0.33 |
| ▸ | RXRB | P28702 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | RARG | P13631 | 5/20 | 0.31 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809982 | 0.78 | HIF1A (0.41) | RXRARARACYP26B1RXRGCYP26A1 | |
| SCHEMBL8310387 | 0.73 | RXRA (0.36) | RXRARARACYP26B1RXRGCYP26A1 | |
| SCHEMBL7624438 | 0.72 | PBRM1 (0.44) | RXRARARARXRGRARBRXRB | |
| SCHEMBL2194526 | 0.70 | MAOB (0.46) | ALDH1A1RXRARARARXRG | |
| SCHEMBL9607758 | 0.69 | KDM4E (0.56) | KDM4EALDH1A1HTTVHLELOC | |
| SCHEMBL10363739 | 0.69 | KDM4E (0.56) | KDM4EALDH1A1HTTVHLELOC | |
| SCHEMBL10364205 | 0.69 | VHL (0.62) | KDM4EALDH1A1HTTVHLELOC | |
| SCHEMBL6915238 | 0.69 | MEN1 (0.51) | — | |
| SCHEMBL8471642 | 0.69 | KDM4E (1.00) | KDM4EALDH1A1HTTVHLELOC | |
| SCHEMBL10890090 | 0.68 | KDM4E (0.54) | KDM4EALDH1A1HTTVHLELOC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1173497-A | Heterocycle-containing carbonic acid derivatives | EISAI CO LTD (JP) | 1998-02-18 | — | — | CN | disclosed |
| EP-0638071-B1 | HETEROCYCLIC CARBONIC ACID DERIVATIVES WHICH BIND TO RETINOID RECEPTORS (RAR) | EISAI CO LTD (JP) | 1997-04-09 | — | — | EP | disclosed |
| US-5612356-A | RETINOID ANTAGONISTS | EISAI CO., LTD. (JP) | 1997-03-18 | — | — | US | disclosed |
| CN-1094052-A | Heterocyclic ring-containing carbonic acid derivatives | EISAI CO LTD (JP) | 1994-10-26 | — | — | CN | disclosed |
| WO-1994014777-A1 | HETEROCYCLIC CARBONIC ACID DERIVATIVES WHICH BIND TO RETINOID RECEPTORS (RAR) | EISAI CO., LTD. (JP) | 1994-07-07 | — | — | WO | disclosed |