Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 15/20 | 0.38 |
| ▸ | RXRG | P48443 | 8/20 | 0.38 |
| ▸ | RXRB | P28702 | 8/20 | 0.38 |
| ▸ | RARA | P10276 | 4/20 | 0.38 |
| ▸ | RARB | P10826 | 7/20 | 0.37 |
| ▸ | RARG | P13631 | 6/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7624438 | 0.88 | PBRM1 (0.44) | HIF1AEPAS1RXRARXRGRXRB | |
| SCHEMBL8310387 | 0.85 | RXRA (0.36) | HIF1AEPAS1RXRARXRGRXRB | |
| SCHEMBL5705158 | 0.81 | RXRA (0.36) | HIF1AEPAS1RXRARXRGRXRB | |
| SCHEMBL6915238 | 0.81 | MEN1 (0.51) | HIF1AEPAS1 | |
| SCHEMBL3061673 | 0.79 | RXRA (0.39) | RXRARXRGRXRBRARARARB | |
| SCHEMBL8809126 | 0.78 | KDM4E (0.53) | RXRARXRGRXRBRARARARB | |
| SCHEMBL2194526 | 0.78 | MAOB (0.46) | RXRARXRGRARA | |
| SCHEMBL8810467 | 0.77 | CDC25B (0.41) | HIF1AEPAS1RXRARXRGRXRB | |
| SCHEMBL15665861 | 0.76 | RXRA (0.41) | RXRARXRGRXRBRARARARB | |
| SCHEMBL8447443 | 0.75 | PBRM1 (0.44) | HIF1AEPAS1PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1173497-A | Heterocycle-containing carbonic acid derivatives | EISAI CO LTD (JP) | 1998-02-18 | — | — | CN | disclosed |
| EP-0638071-B1 | HETEROCYCLIC CARBONIC ACID DERIVATIVES WHICH BIND TO RETINOID RECEPTORS (RAR) | EISAI CO LTD (JP) | 1997-04-09 | — | — | EP | disclosed |
| US-5612356-A | RETINOID ANTAGONISTS | EISAI CO., LTD. (JP) | 1997-03-18 | — | — | US | disclosed |
| CN-1094052-A | Heterocyclic ring-containing carbonic acid derivatives | EISAI CO LTD (JP) | 1994-10-26 | — | — | CN | disclosed |
| WO-1994014777-A1 | HETEROCYCLIC CARBONIC ACID DERIVATIVES WHICH BIND TO RETINOID RECEPTORS (RAR) | EISAI CO., LTD. (JP) | 1994-07-07 | — | — | WO | disclosed |