Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | BAD | Q92934 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 5/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.31 |
| ▸ | DHPS | P49366 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8685833 | 0.87 | HTR6 (0.43) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL8813825 | 0.85 | CYP19A1 (0.39) | MPOKDM4EALDH1A1HTR6 | |
| SCHEMBL8809697 | 0.85 | HTR6 (0.42) | KDM4EALDH1A1HTR6 | |
| Dimethylamine SCHEMBL8812830 | 0.83 | HTR6 (0.43) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL8811856 | 0.82 | DBH (0.41) | KDM4EALDH1A1 | |
| SCHEMBL8811090 | 0.82 | KDM1A (0.38) | PPARGALDH1A1 | |
| SCHEMBL8812495 | 0.82 | TNF (0.39) | ALDH1A1HTR6 | |
| SCHEMBL8812580 | 0.81 | TNF (0.37) | MPOKDM4EHTR6 | |
| SCHEMBL8685781 | 0.81 | HTR6 (0.37) | PDE4APDE4BPDE4CPDE4DMPO | |
| SCHEMBL8809642 | 0.81 | HTR6 (0.36) | KDM4EALDH1A1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |