Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | VSIR | Q9H7M9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808211 | 0.87 | BCHE (0.42) | SMN1; SMN2BCHEPDCD1CD274VSIR | |
| SCHEMBL3379956 | 0.80 | AKT2 (0.44) | KMT2AAKT1ALDH1A1HTT | |
| SCHEMBL3245892 | 0.78 | ROCK2 (0.62) | SMN1; SMN2TP53MEN1KMT2AROCK2 | |
| SCHEMBL21371026 | 0.77 | TP53 (0.43) | SMN1; SMN2TP53MEN1KMT2ATDP1 | |
| SCHEMBL28153807 | 0.76 | AKT2 (0.51) | CD274CYP1A2 | |
| SCHEMBL23752274 | 0.73 | AKT2 (0.54) | CYP1A2 | |
| SCHEMBL3242948 | 0.72 | ROCK2 (0.62) | SMN1; SMN2TP53ROCK2ALDH1A1MAPT | |
| SCHEMBL1978865 | 0.72 | AKT2 (0.55) | SMN1; SMN2MEN1KMT2ATDP1ROCK2 | |
| SCHEMBL17447224 | 0.71 | HTT (0.57) | SMN1; SMN2BCHETP53THRBMEN1 | |
| SCHEMBL9080452 | 0.70 | MEN1 (0.61) | SMN1; SMN2BCHEMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |