Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | F10 | P00742 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SENP5 | Q96HI0 | 2/20 | 0.40 |
| ▸ | SENP2 | Q9HC62 | 2/20 | 0.40 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808371 | 0.96 | KDR (0.46) | KDRF10MAPTNPC1RAB9A | |
| SCHEMBL8807954 | 0.89 | F10 (0.43) | F10MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8809638 | 0.88 | F10 (0.42) | F10MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8810117 | 0.88 | MCHR1 (0.45) | KDRF10MAPTNPC1RAB9A | |
| SCHEMBL8809365 | 0.87 | F10 (0.40) | F10MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8807068 | 0.87 | KCNH2 (0.44) | KDRF10MAPTNPC1RAB9A | |
| SCHEMBL8809575 | 0.87 | F10 (0.41) | F10MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8808106 | 0.86 | F10 (0.41) | F10MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8808363 | 0.85 | MAOA (0.46) | KDRMAOB | |
| SCHEMBL8808236 | 0.85 | MAPT (0.45) | KDRMAPTTP53ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |