Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | YES1 | P07947 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8685509 | 0.92 | POLB (0.50) | PPARGHTR6CYP19A1ALDH1A1NPSR1 | |
| SCHEMBL8811662 | 0.91 | CHRNB2 (0.52) | PPARGALDH1A1MAPTNPSR1FFAR1 | |
| SCHEMBL8813431 | 0.90 | MAPT (0.56) | PPARGHTR6ALDH1A1MAPTNPSR1 | |
| SCHEMBL8810577 | 0.90 | PARP1 (0.51) | CYP19A1ALDH1A1MAPTHTTNPSR1 | |
| SCHEMBL8814248 | 0.88 | ALDH1A1 (0.42) | PPARGALDH1A1MAPTHTTNPSR1 | |
| SCHEMBL8811153 | 0.87 | PPARG (0.53) | PPARGHTR6ALDH1A1MAPTFFAR1 | |
| SCHEMBL8812051 | 0.87 | HTT (0.52) | PPARGCYP19A1ALDH1A1MAPTHTT | |
| SCHEMBL8812572 | 0.86 | PPARG (0.50) | PPARGALDH1A1MAPTHTTNPSR1 | |
| SCHEMBL8810060 | 0.85 | MGAM (0.41) | PPARGCYP19A1ALDH1A1MAPTHTT | |
| SCHEMBL8809683 | 0.85 | FFAR1 (0.57) | PPARGFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |