Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | BCL9 | O00512 | 2/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 1/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | GIPR | P48546 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809779 | 0.89 | GAA (0.52) | GAANPSR1POLBTP53ALDH1A1 | |
| SCHEMBL9056936 | 0.87 | GAA (0.50) | GAANPSR1TP53ALDH1A1UBE2M | |
| SCHEMBL8808422 | 0.86 | TP53 (0.52) | GAANPSR1POLBTP53ALDH1A1 | |
| SCHEMBL8817749 | 0.86 | NPSR1 (0.49) | GAANPSR1POLBTP53ALDH1A1 | |
| SCHEMBL8807180 | 0.86 | GAA (0.49) | GAANPSR1TP53ALDH1A1HRH4 | |
| SCHEMBL8809768 | 0.85 | GAA (0.48) | GAANPSR1POLBTP53ALDH1A1 | |
| SCHEMBL8808615 | 0.84 | CTSD (0.43) | BCL9CTNNB1POLBTP53ALDH1A1 | |
| SCHEMBL8809295 | 0.83 | ALDH1A1 (0.46) | GAANPSR1BCL9CTNNB1ALDH1A1 | |
| SCHEMBL8806837 | 0.82 | GAA (0.45) | GAANPSR1TP53ALDH1A1HRH4 | |
| SCHEMBL8808845 | 0.81 | GAA (0.51) | GAANPSR1TP53ALDH1A1UBE2M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784612-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996010559-A1 | UREA DERIVATIVES AND THEIR USE AS ACAT-INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-04-11 | — | — | WO | disclosed |