Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MAOB | P27338 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4814353 | 0.69 | THRB (0.46) | THRBMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL918406 | 0.67 | MAPT (0.37) | MAPTKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL1047930 | 0.67 | MAPT (0.44) | PGRTHRBMAPTMAOBKDM4E | |
| SCHEMBL4817120 | 0.66 | THRB (0.39) | THRBMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL4813066 | 0.66 | ALDH1A1 (0.50) | THRBMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL4817068 | 0.66 | THRB (0.38) | PGRTHRBMAPTKDM4EALDH1A1 | |
| SCHEMBL27704547 | 0.65 | DHFR (0.44) | KDM4EALDH1A1ATMHSD17B10 | |
| SCHEMBL3234033 | 0.62 | KMT2A (0.40) | PGRTHRBMAPTMAOBKDM4E | |
| SCHEMBL21638399 | 0.62 | MAPT (0.51) | THRBMAPTMAOBKDM4EALDH1A1 | |
| SCHEMBL5654051 | 0.62 | MAPT (0.42) | MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0800519-A1 | STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS, INC. (US) | 1997-10-15 | — | — | EP | claimed |
| WO-1996019458-A2 | STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1996-06-27 | — | — | WO | claimed |