Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 3/20 | 0.63 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.63 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.63 |
| ▸ | ROS1 | P08922 | 1/20 | 0.63 |
| ▸ | FLT3 | P36888 | 1/20 | 0.63 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.63 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | PDE5A | O76074 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387173 | 0.90 | EGFR (0.61) | LMNARAB9AL3MBTL1TSHRNPC1 | |
| SCHEMBL8810873 | 0.80 | PDGFRB (0.68) | LMNAEGFRERBB2FLT3ERBB4 | |
| SCHEMBL29244645 | 0.79 | LMNA (0.68) | LMNARAB9AL3MBTL1TSHRNPC1 | |
| SCHEMBL1680825 | 0.79 | EGFR (0.76) | LMNARAB9ATSHREGFRERBB2 | |
| Benzylphenylether SCHEMBL8809498 | 0.79 | EGFR (0.59) | LMNARAB9AL3MBTL1TSHRNPC1 | |
| SCHEMBL1387226 | 0.77 | EGFR (1.00) | RAB9ANPC1EGFRERBB2CHEK2 | |
| SCHEMBL8809494 | 0.77 | EGFR (0.57) | LMNARAB9AL3MBTL1TSHRNPC1 | |
| SCHEMBL14692125 | 0.77 | LMNA (0.56) | LMNARAB9AL3MBTL1TSHRNPC1 | |
| SCHEMBL8548739 | 0.76 | RAB9A (0.69) | LMNARAB9AL3MBTL1TSHRNPC1 | |
| Hydrochloric Acid SCHEMBL8810027 | 0.76 | EGFR (0.97) | RAB9ANPC1EGFRERBB2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782570-A1 | SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996009294-A1 | SUBSTITUTED HETEROAROMATIC COMPOUNDS AND THEIR USE IN MEDICINE | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |