Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 6/20 | 0.38 |
| ▸ | PGK1 | P00558 | 2/20 | 0.38 |
| ▸ | PGK2 | P07205 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 4/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.34 |
| ▸ | PTPRC | P08575 | 2/20 | 0.34 |
| ▸ | PTPRB | P23467 | 2/20 | 0.34 |
| ▸ | CDC25A | P30304 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8812398 | 0.83 | PTPN5 (0.40) | PTPN5PGK1PGK2PTPN1PTPN2 | |
| SCHEMBL5162415 | 0.81 | PTPN1 (0.42) | PTPN5PGK1PGK2PTPN1PTPN2 | |
| SCHEMBL642521 | 0.79 | ALDH1A1 (0.42) | PTPN5PGK1PGK2KDM4EALDH1A1 | |
| SCHEMBL7598727 | 0.74 | PTPN1 (0.37) | PTPN5PGK1PGK2PTPN1PTPN2 | |
| SCHEMBL642868 | 0.74 | PGK1 (0.42) | PTPN5PGK1PGK2PTPN1 | |
| SCHEMBL5166721 | 0.73 | PTPN1 (0.36) | PTPN5PGK1PGK2PTPN1PTPN2 | |
| SCHEMBL20190977 | 0.72 | PGK1 (0.72) | PTPN5PGK1PGK2PTPN1PTPN2 | |
| SCHEMBL643903 | 0.71 | FDPS (0.34) | PTPN5PTPN1NOS3NOS1NOS2 | |
| SCHEMBL3187016 | 0.71 | ALDH1A1 (0.43) | PTPN1ALDH1A3TYRKDM4EALDH1A1 | |
| SCHEMBL642081 | 0.71 | CA12 (0.40) | PTPN5PGK1PGK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997012903-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR INHIBITING THE BINDING OF PROTEINS CONTAINING AN SH2 DOMAIN TO COGNATE PHOSPHORYLATED PROTEINS | WARNER-LAMBERT COMPANY (US) | 1997-04-10 | — | — | WO | disclosed |