Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | F7 | P08709 | 4/20 | 0.76 |
| ▸ | F3 | P13726 | 4/20 | 0.76 |
| ▸ | PPARG | P37231 | 4/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.76 |
| ▸ | PPARD | Q03181 | 3/20 | 0.76 |
| ▸ | PPARA | Q07869 | 3/20 | 0.76 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.76 |
| ▸ | FABP3 | P05413 | 3/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.76 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.76 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.76 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.76 |
| ▸ | FABP4 | P15090 | 1/20 | 0.76 |
| ▸ | HPGD | P15428 | 1/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.76 |
| ▸ | GNA15 | P30679 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670052 | 1.00 | ALDH1A1 (0.76) | ALDH1A1F7F3PPARGKDM4E | |
| SCHEMBL16299901 | 1.00 | ALDH1A1 (0.76) | ALDH1A1F7F3PPARGKDM4E | |
| SCHEMBL152844 | 1.00 | ALDH1A1 (0.76) | ALDH1A1F7F3PPARGKDM4E | |
| SCHEMBL1962570 | 1.00 | ALDH1A1 (0.76) | ALDH1A1F7F3PPARGKDM4E | |
| SCHEMBL152390 | 1.00 | ALDH1A1 (0.76) | ALDH1A1F7F3PPARGKDM4E | |
| SCHEMBL17053681 | 1.00 | ALDH1A1 (0.76) | ALDH1A1F7F3PPARGKDM4E | |
| SCHEMBL7136005 | 1.00 | ALDH1A1 (0.76) | ALDH1A1F7F3PPARGKDM4E | |
| SCHEMBL13385648 | 1.00 | ALDH1A1 (0.76) | ALDH1A1F7F3PPARGKDM4E | |
| SCHEMBL7136003 | 1.00 | ALDH1A1 (0.76) | ALDH1A1F7F3PPARGKDM4E | |
| SCHEMBL152845 | 1.00 | ALDH1A1 (0.76) | ALDH1A1F7F3PPARGKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11911475-B2 | Low molecular weight cationic lipids for oligonucleotide delivery | SIRNA THERAPEUTICS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-20180208545-A1 | NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY | SIRNA THERAPEUTICS, INC. (US) | 2018-07-26 | — | — | US | disclosed |
| US-20180195071-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | BANK OF AMERICA, N.A. | 2018-07-12 | — | — | US | disclosed |
| EP-3330377-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | Sirna Therapeutics, Inc. (US) | 2018-06-06 | — | — | EP | disclosed |
| US-9981907-B2 | Low molecular weight cationic lipids for oligonucleotide delivery | SIRNA THERAPEUTICS, INC. (US) | 2018-05-29 | — | — | US | disclosed |
| US-9970005-B2 | RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-20180100154-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | BANK OF AMERICA, N.A. | 2018-04-12 | — | — | US | disclosed |
| US-20180030454-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | BANK OF AMERICA, N.A. | 2018-02-01 | — | — | US | disclosed |
| US-9879262-B2 | RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) | SIRNA THERAPEUTICS, INC. (US) | 2018-01-30 | — | — | US | disclosed |
| US-20180000939-A1 | NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY | SIRNA THERAPEUTICS, INC. (US) | 2018-01-04 | — | — | US | disclosed |
| US-20130150433-A1 | RNA Interference Mediated Inhibition of Hepatitis B Virus (HBV) Gene Expression Using Short Interfering Nucleic Acid (siNA) | BANK OF AMERICA, N.A. | 2013-06-13 | — | — | US | disclosed |
| US-20130150433-A1 | RNA Interference Mediated Inhibition of Hepatitis B Virus (HBV) Gene Expression Using Short Interfering Nucleic Acid (siNA) | BANK OF AMERICA, N.A. | 2013-06-13 | — | — | US | disclosed |
| US-20130137752-A1 | RNA Interference Mediated Inhibition of Catenin (Cadherin-Associated Protein), Beta 1 (CTNNB1) Gene Expression Using Short Interfering Nucleic Acid (siNA) | BANK OF AMERICA, N.A. | 2013-05-30 | — | — | US | disclosed |
| US-20130137752-A1 | RNA Interference Mediated Inhibition of Catenin (Cadherin-Associated Protein), Beta 1 (CTNNB1) Gene Expression Using Short Interfering Nucleic Acid (siNA) | BANK OF AMERICA, N.A. | 2013-05-30 | — | — | US | disclosed |
| WO-2012058210-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |
| WO-2012054365-A2 | NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY | MERCK SHARP & DOHME CORP. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012040184-A2 | NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY | MERCK SHARP & DOHME CORP. (US) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012027467-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | MERCK SHARP & DOHME CORP. (US) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012024170-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | MERCK SHARP & DOHME CORP. (US) | 2012-02-23 | — | — | WO | disclosed |
| WO-2012018754-A2 | RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | MERCK SHARP & DOHME CORP. (US) | 2012-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180208545-A1 | NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY | LDLR, APOB, CETP | ALDH1A1 4239/4885F7 2569/4885F3 1822/4885 |
| US-20180000939-A1 | NOVEL LOW MOLECULAR WEIGHT CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY | LDLR, APOB, CETP | ALDH1A1 3740/4885F7 1550/4885F3 1815/4885 |
| US-20180100154-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF PROLYL HYDROXYLASE DOMAIN 2 (PHD2) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | EGLN2, EGLN3, EGLN1 | ALDH1A1 1024/4885F7 4870/4885F3 3923/4885 |
| US-20180195071-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) | HAVCR2, SRRT, AGO2 | ALDH1A1 3171/4885F7 4494/4885F3 2123/4885 |
| US-11911475-B2 | Low molecular weight cationic lipids for oligonucleotide delivery | LDLR, APOB, CETP | ALDH1A1 4090/4885F7 2163/4885F3 1540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.