Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.50 |
| ▸ | PARP1 | P09874 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8685513 | 0.91 | CYP19A1 (0.47) | HTR6KMT2ACHRNB2CHRNA7CHRNA4 | |
| SCHEMBL8810496 | 0.90 | HTR6 (0.49) | HTR6PARP1CYP19A1LMNAHTT | |
| SCHEMBL8810585 | 0.89 | PARP1 (0.51) | PARP1KMT2APOLBCYP19A1MEN1 | |
| SCHEMBL8811671 | 0.89 | CHRNB2 (0.51) | PARP1CHRNB2CHRNA7CHRNA4POLB | |
| SCHEMBL8811167 | 0.86 | HTR6 (0.53) | HTR6PARP1CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL8812059 | 0.86 | CYP19A1 (0.50) | PARP1KMT2APOLBCYP19A1MEN1 | |
| SCHEMBL8811933 | 0.86 | HTR6 (0.41) | HTR6PARP1 | |
| SCHEMBL8814259 | 0.84 | TNF (0.41) | HTR6PARP1POLBCYP19A1LMNA | |
| SCHEMBL8810072 | 0.84 | PARP1 (0.41) | PARP1KMT2ACHRNB2CHRNA7CHRNA4 | |
| SCHEMBL8809696 | 0.84 | PPARG (0.41) | HTR6KMT2ACHRNB2CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |