Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811123 | 0.92 | ALDH1A1 (0.51) | PARP1ALDH1A1CYP19A1SMN1; SMN2LMNA | |
| SCHEMBL8810585 | 0.90 | PARP1 (0.51) | PARP1ALDH1A1CYP19A1SMN1; SMN2LMNA | |
| SCHEMBL8685513 | 0.88 | CYP19A1 (0.47) | ALDH1A1CYP19A1LMNAPOLBMEN1 | |
| SCHEMBL8814259 | 0.88 | TNF (0.41) | PARP1ALDH1A1CYP19A1SMN1; SMN2LMNA | |
| SCHEMBL8809453 | 0.86 | MPO (0.38) | PARP1ALDH1A1CYP19A1SMN1; SMN2LMNA | |
| SCHEMBL8810564 | 0.85 | NPC1 (0.39) | PARP1ALDH1A1CYP19A1SMN1; SMN2LMNA | |
| SCHEMBL8811311 | 0.85 | NPC1 (0.50) | ALDH1A1CYP19A1SMN1; SMN2LMNAMGAM | |
| SCHEMBL8810496 | 0.85 | HTR6 (0.49) | PARP1ALDH1A1CYP19A1LMNAHTT | |
| SCHEMBL8813439 | 0.84 | HTR6 (0.50) | PARP1CYP19A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL8811671 | 0.84 | CHRNB2 (0.51) | PARP1POLBCHRNB2CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | claimed |
| EP-0780389-A1 | Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1997-06-25 | — | — | EP | disclosed |