Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9081508 | 1.00 | SMN1; SMN2 (0.60) | SMN1; SMN2GAALMNAPOLBTP53 | |
| SCHEMBL1340139 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2GAALMNAPOLBTP53 | |
| SCHEMBL1341401 | 0.81 | SMN1; SMN2 (0.70) | SMN1; SMN2GAALMNAPOLBTP53 | |
| SCHEMBL6220893 | 0.81 | MAPT (0.74) | SMN1; SMN2GAALMNAPOLBTP53 | |
| SCHEMBL9080024 | 0.78 | RAB9A (0.50) | SMN1; SMN2GAAPOLBTP53HTT | |
| SCHEMBL8809685 | 0.78 | RAB9A (0.50) | SMN1; SMN2GAAPOLBTP53HTT | |
| SCHEMBL11368738 | 0.77 | SMN1; SMN2 (0.72) | SMN1; SMN2GAALMNAPOLBTP53 | |
| SCHEMBL11370116 | 0.76 | LMNA (0.75) | SMN1; SMN2GAALMNAPOLBTP53 | |
| SCHEMBL11009364 | 0.75 | SMN1; SMN2 (0.69) | SMN1; SMN2GAALMNAPOLBTP53 | |
| SCHEMBL9232215 | 0.75 | GAA (1.00) | SMN1; SMN2GAALMNAPOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527736-B1 | ISOXAZOLE-4-CARBOXAMIDES AND HYDROXYALKYLIDENE-CYANOACETAMIDES, DRUGS CONTAINING THESE COMPOUNDS AND USE OF SUCH DRUGS | HOECHST AG (DE) | 1997-04-16 | — | — | EP | disclosed |
| US-5532259-A | ANTITUMOR | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-02 | — | — | US | disclosed |
| US-5494911-A | TREATING LEUKEMIA, SARCOMA, CARCINOMA, LYMPHOMA, SKIN CANCER | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-02-27 | — | — | US | disclosed |