Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLRMT | O00411 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.33 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13667820 | 0.88 | POLRMT (0.36) | POLRMTRIPK1DOT1LACVRL1TNK2 | |
| SCHEMBL881726 | 0.84 | ADORA2A (0.31) | ACVRL1STING1 | |
| SCHEMBL24791271 | 0.81 | NPC1 (0.37) | POLRMTRIPK1DOT1LTNK2STING1 | |
| SCHEMBL10187239 | 0.80 | POLRMT (0.51) | POLRMT | |
| SCHEMBL18697877 | 0.79 | ADORA2A (0.38) | POLRMTDOT1L | |
| SCHEMBL881487 | 0.79 | ADORA2A (0.38) | POLRMTDOT1L | |
| SCHEMBL10101470 | 0.78 | POLRMT (0.34) | POLRMTDOT1LACVRL1MAP4K4 | |
| SCHEMBL10101469 | 0.76 | POLRMT (0.34) | POLRMTDOT1LACVRL1MAP4K4 | |
| SCHEMBL18480780 | 0.76 | POLRMT (0.36) | POLRMTDOT1LACVRL1MAP4K4 | |
| SCHEMBL18470925 | 0.76 | POLRMT (0.36) | POLRMTDOT1LACVRL1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012039791-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012039787-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2012-03-29 | — | — | WO | disclosed |