Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 8/20 | 0.65 |
| ▸ | CHRM3 known ✓ | P20309 | 8/20 | 0.65 |
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.65 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.65 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.65 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.65 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.65 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.65 |
| ▸ | HTR1A | P08908 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.65 |
| ▸ | PGR | P06401 | 1/20 | 0.65 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.65 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.65 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.65 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.65 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL119825 | 0.97 | CHRM1 (0.68) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL25099736 | 0.88 | ALDH1A1 (0.59) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL29221460 | 0.85 | CHRM1 (0.60) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL30860674 | 0.84 | CHRM1 (0.54) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL9298334 | 0.83 | RAD52 (0.59) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Suxamethonium SCHEMBL2821312 | 0.82 | ADRA2A (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL8945377 | 0.82 | CHRM5 (0.50) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL1157050 | 0.82 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL9022612 | 0.81 | CHRM1 (0.56) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL3788608 | 0.81 | CHRM5 (0.73) | CHRM1CHRM3CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647133-A4 | COMPOSITIONS AND METHODS FOR ENHANCED DRUG DELIVERY. | AFFYMAX TECH NV (AN) | 1997-10-29 | — | — | EP | disclosed |
| US-5607691-A | IONTOPHORESIS | AFFYMAX TECHNOLOGIES N.V. (GB) | 1997-03-04 | — | — | US | disclosed |
| EP-0647133-A1 | COMPOSITIONS AND METHODS FOR ENHANCED DRUG DELIVERY | AFFYMAX TECHNOLOGIES N.V. (AN) | 1995-04-12 | — | — | EP | disclosed |
| WO-1993025197-A1 | COMPOSITIONS AND METHODS FOR ENHANCED DRUG DELIVERY | AFFYMAX TECHNOLOGIES N.V. (AN) | 1993-12-23 | — | — | WO | disclosed |