Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 15/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | USP1 | O94782 | 1/20 | 0.37 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8818444 | 0.84 | ADORA2A (0.56) | TGFBR1MAPK14ADORA2AALDH1A1CYP1A2 | |
| SCHEMBL8815685 | 0.84 | TGFBR1 (0.51) | TGFBR1MAPK14ADORA2ACCR1CCR8 | |
| SCHEMBL8818447 | 0.82 | ADORA2A (0.54) | TGFBR1MAPK14ADORA2A | |
| SCHEMBL8818439 | 0.82 | TGFBR1 (0.49) | TGFBR1MAPK14CYP1A2CYP2D6 | |
| SCHEMBL8815690 | 0.82 | TGFBR1 (0.49) | TGFBR1MAPK14ADORA2AALDH1A1CYP1A2 | |
| SCHEMBL8818617 | 0.81 | MEN1 (0.46) | TGFBR1MAPK14ADORA2AALDH1A1TSHR | |
| SCHEMBL8816938 | 0.81 | TGFBR1 (0.50) | TGFBR1MAPK14ADORA2ACCR1CCR8 | |
| SCHEMBL8814758 | 0.80 | TGFBR1 (0.47) | TGFBR1MAPK14 | |
| SCHEMBL8819278 | 0.80 | TGFBR1 (0.47) | TGFBR1MAPK14ADORA2ACCR1CCR8 | |
| SCHEMBL8818639 | 0.80 | TGFBR1 (0.47) | TGFBR1MAPK14CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012066122-A1 | 2 - (PYRIDIN- 2 -YL) -QUINAZOLINE DERIVATIVES AND THEIR USE AS MICROBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-05-24 | — | — | WO | disclosed |