Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.42 |
| ▸ | AHR | P35869 | 2/20 | 0.42 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8818624 | 0.88 | GAA (0.51) | TP53SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL8816575 | 0.87 | ADORA2A (0.62) | TP53SMN1; SMN2ADORA2AMEN1KMT2A | |
| SCHEMBL6120916 | 0.83 | TGFBR1 (0.54) | ADORA2AMEN1KMT2ATGFBR1MAPK14 | |
| SCHEMBL8816445 | 0.82 | TGFBR1 (0.46) | ADORA2AMEN1KMT2ATGFBR1MAPK14 | |
| SCHEMBL8819077 | 0.82 | ADORA2A (0.56) | TP53SMN1; SMN2ADORA2AMEN1KMT2A | |
| SCHEMBL8814729 | 0.82 | NR1I3 (0.54) | SMN1; SMN2MEN1KMT2AMAPTNPSR1 | |
| SCHEMBL8819429 | 0.81 | TGFBR1 (0.48) | ADORA2AMEN1KMT2ATGFBR1MAPK14 | |
| SCHEMBL8816177 | 0.80 | NR1I3 (0.51) | TGFBR1MAPK14NR1I3LMNA | |
| SCHEMBL8815752 | 0.80 | MEN1 (0.51) | ADORA2AMEN1KMT2AMAPTHPGD | |
| SCHEMBL8815695 | 0.80 | ADORA2A (0.58) | ADORA2AMEN1KMT2ATGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012066122-A1 | 2 - (PYRIDIN- 2 -YL) -QUINAZOLINE DERIVATIVES AND THEIR USE AS MICROBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-05-24 | — | — | WO | disclosed |