Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.50 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27837485 | 0.86 | PDE10A (0.42) | MKNK2PRKCZCYP11B2KHKLMNA | |
| SCHEMBL568363 | 0.83 | CYP11B2 (0.55) | MKNK2CYP11B2NR3C1CYP17A1CYP1A2 | |
| SCHEMBL31691962 | 0.82 | ALDH1A1 (0.53) | MKNK2CYP11B2KHKNR3C1MAP4K1 | |
| SCHEMBL13836976 | 0.79 | CHEK1 (0.50) | CYP11B2NR3C1 | |
| SCHEMBL25269630 | 0.78 | CYP11B2 (0.47) | CYP11B2KHKNR3C1MAPK1 | |
| SCHEMBL10005684 | 0.76 | MKNK2 (0.48) | MKNK2LMNAMAPTALDH1A1CDC7 | |
| Isonicotinic Acid SCHEMBL27937036 | 0.73 | PIM3 (0.47) | CYP11B2NR3C1MAPTALDH1A1MAPK1 | |
| SCHEMBL13836272 | 0.73 | NR3C1 (0.57) | CYP11B2NR3C1 | |
| SCHEMBL27918383 | 0.73 | NR3C1 (0.35) | CYP11B2KHKNR3C1ALDH1A1MEN1 | |
| SCHEMBL15402620 | 0.71 | MKNK2 (0.43) | MKNK2CYP11B2MAPTPDE10AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102153551-B | Indazole/azaindazole-based diarylcarbamide/thiocarbamide-structure antineoplastic drug | JINAN HAILE MEDICAL TECHNOLOGY DEV CO LTD | 2012-04-25 | — | — | CN | disclosed |
| WO-2011120327-A9 | ANTI-TUMOR MEDICAMENT OF STRUCTURE OF DIARYLUREA OR THIOUREA KIND BASED ON INDAZOLE OR AZA-INDAZOLE | 济南海乐医药技术开发有限公司 (CN) | 2012-03-29 | — | — | WO | disclosed |
| WO-2011120327-A1 | ANTI-TUMOR MEDICAMENT OF STRUCTURE OF DIARYLUREA OR THIOUREA KIND BASED ON INDAZOLE OR AZA-INDAZOLE | 济南海乐医药技术开发有限公司 (CN) | 2011-10-06 | — | — | WO | disclosed |
| CN-102153551-A | Indazole/azaindazole-based diarylcarbamide/thiocarbamide-structure antineoplastic drug | JINAN HAILE MEDICAL TECHNOLOGY DEV CO LTD | 2011-08-17 | — | — | CN | disclosed |