Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.62 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 15/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7647035 | 1.00 | OPRK1 (0.62) | OPRK1BLMMEN1LMNAMAPK1 | |
| Fumaric Acid SCHEMBL7947009 | 1.00 | OPRK1 (0.62) | OPRK1BLMMEN1LMNAMAPK1 | |
| SCHEMBL7921100 | 0.95 | OPRK1 (0.68) | OPRK1BLMUTS2ROPRD1CYP3A4 | |
| Fumaric Acid SCHEMBL10417793 | 0.89 | HPGD (0.51) | OPRK1BLMMEN1LMNAMAPK1 | |
| Maleic Acid SCHEMBL9734427 | 0.86 | OPRK1 (0.71) | OPRK1BLMMEN1LMNAMAPK1 | |
| Fumaric Acid SCHEMBL9734432 | 0.86 | OPRK1 (0.71) | OPRK1BLMMEN1LMNAMAPK1 | |
| Maleic Acid SCHEMBL10379013 | 0.81 | OPRK1 (0.63) | OPRK1BLMMEN1LMNAMAPK1 | |
| Fumaric Acid SCHEMBL10417814 | 0.80 | BLM (0.81) | OPRK1BLMMEN1LMNAMAPK1 | |
| Fumaric Acid SCHEMBL10417816 | 0.80 | BLM (0.81) | OPRK1BLMMEN1LMNAMAPK1 | |
| SCHEMBL9515474 | 0.79 | OPRK1 (0.80) | OPRK1BLMUTS2ROPRD1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222886-A1 | COMPOSITIONS AND METHODS TO TREAT POLYCYSTIC KIDNEY DISEASE | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-1997033580-A1 | MAINTAINING KIDNEY FUNCTION DURING SURGERY OR TRAUMA | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 1997-09-18 | — | — | WO | disclosed |