Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | CD69 | Q07108 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7169786 | 0.88 | KDM4E (0.58) | PKMKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL8875720 | 0.85 | ABCB1 (0.48) | KDM4EALDH1A1HPGDL3MBTL1SMN1; SMN2 | |
| SCHEMBL9038528 | 0.83 | L3MBTL1 (0.46) | PKMKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL8874954 | 0.83 | PTGDR2 (0.50) | PKMKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL8822606 | 0.81 | PTGDR2 (0.48) | PKMKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL17681784 | 0.81 | CA12 (0.47) | KDM4EALDH1A1HPGDTDP1POLB | |
| SCHEMBL3241147 | 0.80 | PKM (0.64) | PKMKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL19475267 | 0.80 | AKR1B1 (0.56) | KDM4EALDH1A1HPGDTDP1POLB | |
| SCHEMBL5386792 | 0.75 | L3MBTL1 (0.65) | KDM4EALDH1A1HPGDTDP1L3MBTL1 | |
| SCHEMBL9646424 | 0.74 | KMT2A (0.66) | PKMKDM4EALDH1A1HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5637624-A | ANTISEROTONIN AGENT | ELI LILLY AND COMPANY (US) | 1997-06-10 | — | — | US | disclosed |
| EP-0471515-B1 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes and 3-aminothiochromanes | LILLY CO ELI (US) | 1997-03-05 | — | — | EP | disclosed |
| US-5594034-A | ADMINISTERING DIRECT ACTING 5-HYDROXYTRYPTAMINE AGONIST TO MAMMAL | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5594025-A | Method of inhibiting gastric acid secretion with 5-substituted-3-aminochromane | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0455510-B1 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | LILLY CO ELI (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5576352-A | Method of inhibiting gastric acid secretion with aryloxypropanolamines | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| US-5571942-A | Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes | ELI LILLY AND COMPANY (US) | 1996-11-05 | — | — | US | disclosed |
| US-5552444-A | AGONIST ACTIVITY AT SEROTONIN RECEPTORS, ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1996-09-03 | — | — | US | disclosed |
| EP-0712837-A2 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes and 3-aminochromanes | ELI LILLY AND COMPANY (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5470977-A | Serotonin 1A receptor agonists | ELI LILLY AND COMPANY (US) | 1995-11-28 | — | — | US | disclosed |
| EP-0385658-B1 | Ring-substituted 2-amino 1,2,3,4-tetra-hydronaphthalenes and 3-aminochromanes | LILLY CO ELI (US) | 1994-12-28 | — | — | EP | disclosed |
| US-5340838-A | Administering serotonin agonist to mammals | ELI LILLY AND COMPANY (US) | 1994-08-23 | — | — | US | disclosed |
| US-5286753-A | Serotonin 1a receptor agonists | ELI LILLY AND COMPANY (US) | 1994-02-15 | — | — | US | disclosed |
| US-5258379-A | ADMINISTERING IN AN EFFECTIVE DOSAGE TO MAMMALS | ELI LILLY AND COMPANY (US) | 1993-11-02 | — | — | US | disclosed |
| US-5158956-A | Administering serotonin receptor agonist | ELI LILLY AND COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0498590-A1 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes | ELI LILLY AND COMPANY (US) | 1992-08-12 | — | — | EP | disclosed |
| US-5096908-A | 5-HT1A agonist | ELI LILLY AND COMPANY (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0471515-A1 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes and 3-aminothiochromanes | ELI LILLY AND COMPANY (US) | 1992-02-19 | — | — | EP | disclosed |
| EP-0455510-A2 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | ELI LILLY AND COMPANY (US) | 1991-11-06 | — | — | EP | disclosed |
| EP-0385658-A1 | Ring-substituted 2-amino 1,2,3,4-tetra-hydronaphthalenes and 3-aminochromanes | ELI LILLY AND COMPANY (US) | 1990-09-05 | — | — | EP | disclosed |