Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 9/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765091 | 0.86 | CARM1 (0.39) | HDAC1HDAC2HDAC3HTR4CHRM3 | |
| SCHEMBL21578753 | 0.84 | HDAC1 (0.38) | HDAC1HDAC2HDAC3HTR4CHRM3 | |
| SCHEMBL23870932 | 0.82 | HTR4 (0.39) | HDAC1HDAC2HDAC3HTR4CHRM3 | |
| SCHEMBL19765231 | 0.82 | NCF1 (0.41) | HDAC1HDAC2HDAC3HTR4CHRM3 | |
| SCHEMBL19088390 | 0.81 | HDAC1 (0.36) | HDAC1HDAC2HDAC3HTR4CHRM3 | |
| SCHEMBL15998174 | 0.79 | ACACB (0.39) | HDAC1HDAC2HDAC3 | |
| SCHEMBL19651224 | 0.79 | NCF1 (0.42) | HDAC1HDAC2HDAC3HTR4CHRM3 | |
| SCHEMBL1813937 | 0.78 | CHRM3 (0.43) | HDAC1HDAC2HDAC3HTR4CHRM3 | |
| SCHEMBL26785169 | 0.77 | HTR4 (0.40) | HDAC1HDAC2HDAC3HTR4CHRM3 | |
| SCHEMBL22644011 | 0.76 | TLR7 (0.36) | HDAC1HDAC2HDAC3HTR4CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150608-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | Gilead Sciences, Inc. (US) | 2017-04-05 | — | — | EP | disclosed |
| EP-2937350-A1 | 1' -substituted carba-nucleoside analogs for antiviral treatment | GILEAD SCIENCES, INC. (US) | 2015-10-28 | — | — | EP | disclosed |
| EP-2268642-B1 | 1' -SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES INC (US) | 2015-02-25 | — | — | EP | disclosed |
| WO-2012039791-A1 | 2' -FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT | GILEAD SCIENCES, INC. (US) | 2012-03-29 | — | — | WO | disclosed |