Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29791345 | 0.76 | PDK1 (0.46) | HPGDL3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL1430242 | 0.73 | MAPT (0.50) | HPGDSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL307353 | 0.72 | — | — | |
| SCHEMBL30662726 | 0.72 | — | — | |
| SCHEMBL20040913 | 0.72 | LTA4H (0.46) | HPGDSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL14106778 | 0.71 | CA1 (0.55) | HPGDL3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL10625640 | 0.71 | MAPT (0.46) | HPGDL3MBTL1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL1189820 | 0.71 | PDE4D (0.44) | HPGDRAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL2356967 | 0.71 | MAPT (0.48) | HPGDL3MBTL1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL8075826 | 0.71 | RAB9A (0.45) | HPGDSMN1; SMN2RAB9ANPC1PSIP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021094974-A1 | HETEROCYCLIC TRPML1 AGONISTS | LIBRA THERAPEUTICS, INC. (US) | 2021-05-20 | — | — | WO | disclosed |
| US-8455252-B2 | Materials and methods for sensitizing multidrug resistant cells | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORP. (US) | 2013-06-04 | — | — | US | disclosed |
| US-5656658-A | Method for the treatment of anxiety | ASTRA AKTIEBOLAG (SE) | 1997-08-12 | — | — | US | disclosed |
| US-5646309-A | Intermediates in the synthesis of chroman derivatives | ASTRA AKTIEBOLAG (SE) | 1997-07-08 | — | — | US | disclosed |
| US-5639772-A | Chroman derivatives | ASTRA AKTIEBOLAG (SE) | 1997-06-17 | — | — | US | disclosed |
| US-5639784-A | ADMINISTERING 3-AMINO-5-CARBAMOYL-CHROMENES AND DERIVATIVES | ASTRA AKTIEBOLAG (SE) | 1997-06-17 | — | — | US | disclosed |