Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8825439 | 0.85 | KDM4E (0.46) | KDM4ETSHRALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8825427 | 0.80 | HDAC6 (0.38) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL8825474 | 0.79 | KDM4E (0.45) | KDM4ETSHRALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8825306 | 0.77 | KDM4E (0.48) | KDM4ETSHRALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8825252 | 0.74 | KDM4E (0.46) | KDM4ETSHRALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8825338 | 0.72 | TSHR (0.42) | KDM4ETSHRALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL19065281 | 0.71 | ALDH1A1 (0.46) | KDM4ETSHRALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9212971 | 0.70 | ALDH1A1 (0.44) | TSHRALDH1A1HPGDHSD17B10HTT | |
| SCHEMBL8825644 | 0.70 | KDM4E (0.42) | KDM4ETSHRALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8825231 | 0.69 | EGFR (0.33) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624943-A | Pyridine compounds which are useful as leukotriene-B4 -antagonists | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-04-29 | — | — | US | disclosed |
| EP-0651745-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B 4? ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002464-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B4 ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-02-03 | — | — | WO | disclosed |